The availability and necessity of vitamin E in equine diets is well established. When healthy horses are given frequent access to fresh forage such as good-quality pasture, there is little need for supplementation of vitamin E. However, many horses today are managed without fresh forage in their diets. These horses can survive in such management systems, but they will likely not be consuming sufficient vitamin E for optimal health.
Vitamin E is first and foremost an antioxidant, an agent that keeps free radicals from forming and potentially weakening cells and tissues. In addition to its antioxidant responsibilities, vitamin E is vital to immune, cardiovascular, circulatory, neuromuscular, and reproductive functions. Therefore, supplementation with an effective vitamin E supplement is recommended for all horses that do not have access to growing pasture.
Research has revealed that vitamin E varies in its potency, based on whether it is natural or synthetic. The chemical structures of synthetic and natural vitamin E differ. Natural vitamin E is recognized as "d-alpha-tocopherol," and is made up of a single isomer. Synthetic vitamin E, termed "dl-alpha tocopherol," contains a mixture of eight different isomers, four tocopherols and four tocotrienols. Of these eight, only one is molecularly equivalent to natural vitamin E. Sources of natural vitamin E, especially Nano-E, more effectively raise serum levels when compared to synthetic.
Alpha-tocopherol is the form of vitamin E that is most abundant in the body, and is therefore the most appropriate for use in supplementation.
To make alpha-tocopherol stable in supplements, it must be chemically joined with an acid during manufacture, a process called esterification. The acid, in this case acetate, acts as a padlock or protective cap that shields alpha-tocopherol from the damages caused by exposure to oxidative forces. Without esterification, alpha-tocopherol can quickly denature, losing its antioxidant properties and rendering it ineffective.
Once ingested, esterified alpha-tocopherol is subjected to normal digestive enzymes. A certain group of enzymes called esterases are chemically capable of unlocking the padlock created through esterification. Once free, alphatocopherol is available for absorption with its antioxidant properties intact.
Fat-soluble vitamins like vitamin E must be offered to horses in such a way that maximizes absorption. Before vitamin E can be absorbed, it must become water-soluble or dispersible in liquid. This presents a challenge: As everyone knows, oil and water don't mix.
Researchers developed a method by which fat-soluble vitamins can be absorbed with great efficiency. Because of its oily nature, vitamin E is hydrophobic (water-shunning). To overcome this, researchers use proprietary technology to encapsulate the vitamin E in nanoparticles and then surround each nanoparticle with a hydrophilic (water-loving) outer layer.. The hydrophilic outer layer allows the nanoparticles to be rapidly and evenly released in water-based environments such as the gastrointestinal tract.
The greatest benefit of this unique delivery system is an increase in the bioavailability of vitamin E. The more vitamin E that is absorbed into the bloodstream, the more available it is for use as a body-wide antioxidant essential for tissue repair and for its imperative roles in various body systems.
Controlled studies at Kentucky Equine Research indicate that Nano-E is superior to synthetic and other natural vitamin E sources.
Horses that do not have access to pasture may not be consuming optimal levels of vitamin E. Nano•E provides this essential vitamin in a form that is easily absorbed, and is appropriate for horses of all ages that are stalled due to training schedules, travel, or injury.
Horses asked to work strenuously benefi t from Nano•E. A regular schedule of training and competition make performance horses susceptible to muscle damage, which is due largely to oxidative stress. Nano•E provides fast-acting antioxidant protection for hard-working horses.
Appropriate for broodmares and stallions, Nano•E provides optimal antioxidant protection. Broodmares benefi t from increased fertility and increased transfer of passive immunity to their foals. Vitamin E supplementation has been linked to increased libido and semen quality in stallions.
Veterinarians and researchers have found that vitamin E supplementation often helps in the recovery of certain neurological problems. Nano•E provides natural-source vitamin E in a form that is quickly absorbed.
Prior to relocation, long-distance travel, weaning, or other stress-inducing events, Nano-E provides a boost to antioxidant and immune defenses.
Following injuries such as lacerations, puncture wounds, or burns, the addition of Nano-E to the diet will increase antioxidant activity and enhance recovery.
Daily Use: give 4-8 mL (1000-2000 IU) per 1100 lb (500 kg) horse by mouth or top-dress on feed.
Pre-Competition: give 12-20 mL (3000-5000 IU) per 1100 lb (500 kg) horse 6-12 hours prior to competition or stressful event.
Guaranteed Analysis: 250 IU d-alpha-tocopherol per mL
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